Abhya Vij

By William & Mary

$1,555
Donated
25% of $6,000 goal
10
Donors
This campaign ended on April 23, 2016, but you can still make a gift to William & Mary by clicking here!
About

Orexin B Mediated Restoration of Attentional Performance in Animal Models of Alzheimer's

As the global population ages we have the fortune of watching as decades of research comes together to prolong the lives of our loved ones. Unfortunately, an aging brain can dampen our quality of life dramatically. Of the top 10 causes of death in America, Alzheimer's is the only one with no prevention, cure, or treatment to slow it down. Scientists have found that one hallmark sign of imminent neurocognitive disease is changes in response to homeostatic functions, like sleep cycles and dietary habits.
The basal forebrain has been implicated in attentional performance and response to homeostatic cues. Researchers have found a particular group of neurons in this region that have receptors for excitatory neuropeptides called orexins. In patients experiencing aging-related cognitive decline, the degeneration of these neurons is considered a marker for disorders like Alzheimer's and Parkinson's. Because there are fewer neurons with orexin receptors in old age, there is lessened firing of action potentials in the basal forebrain. This lessened firing is what causes the hallmark changes in homeostatic functions.  A novel technique for treatment of these disorders would be to administer additional orexins, causing increased rates of firing in the remaining neurons to compensate for the degenerated neurons.

All William & Mary Honors Honors Fellowships fundraising supports the Charles Center Honors Fellowships Fund. Direct support for individual undergraduate research projects is distributed by the Roy R. Charles Center for Academic Excellence. To learn more about Honors Fellowships, please visit our About page. If you have questions, please visit our FAQ page.


No updates for this campaign.


Donor Map
Donor Affiliations
Book icon10%Students
Gradhat icon40%Alumni
Parent icon20%Parents
Friends icon40%Friends
Most Recent Donors
Katherine Webb photo
Katherine Webb
Mona Vij photo
Mona Vij
An Anonymous Donor
Anonymous
Mark Sweeney photo
Mark Sweeney
An Anonymous Donor
Anonymous
Tina  and Matt Williams photo
Tina and Matt Williams
Zoe White photo
Zoe White
An Anonymous Donor
Anonymous
An Anonymous Donor
Anonymous
An Anonymous Donor
Anonymous
View All Donors

Advocates

Mitch VanderVorst photo
generated 729 clicks and 5 gifts, totaling $460
Community Advocates photo
generated 6 clicks